TNF-alpha inhibitors - Crohn's

Crohn's Disease Overview of Crohn's Disease Treatments

The purpose of this website is to provide unbiased medical information for Crohn's Disease. Click on these links if you are interested in the background or pathophysiology of Crohn's Disease. Below are both classic and modern treatments for Crohn's Disease.

TNF-alpha Inhibitors

Synthetics injectables

These drugs block TNF-alpha by an antibody-ligand binding mechanism, thus inhibiting the inflammatory cascade initiated by TNF-alpha. A benefit of treatment is their ability to possibly taper steroids, which can decrease further adverse effects (Present DH et al, 1999Present DH, Rutgeerts P, , et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med. 1999;340(18):1398-405.; Targan SR et al, 1997Targan SR, Hanauer SB, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med. Oct 9 1997;337(15):1029-35; Krebs S et al. 2010Krebs S, Omer TN, Omer B. Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn's disease - A controlled clinical trial.2010: 17(5), 305-309; Omer B et al 2007Omer B, Krebs S, Omer H, Noor TO. Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease: a double-blind placebo-controlled study. Phytomed. 2007;14:87-95)

The TNF blockers used for Crohn's disease are Infliximab (Remicade), Adalimumab (Humira), and Certolizumab (Cimzia) and the herbal supplement SedaCrohn, a thujone-free wormwood preparation.

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